Life on a chip - vascularized micro-tumor chips for mimicking clinical drug responses

In this webinar, you will learn about cutting-edge organ chip technology already in use by several of the top pharmaceutical companies for drug development and immuno-oncology applications. Most cells in our body are no farther from a blood vessel than the width of a hair. Blood vessels help pattern tissues and provide them with their nutrients, and since almost all therapeutics — whether small molecules, antibodies, or leukocytes — reach our tissues via blood vessels, no model of tissue-drug interaction is realistic without this supporting vascular network. You will learn what readouts are available in vitro for developing drug, cell and gene-based therapies, including:

• Continual imaging of tumor growth and response to drugs
• Imaging of leukocyte vascular adhesion & extravasation
• Assessment of tumor occupancy and killing by leukocytes, including CAR-Ts
• Assessment of monoclonal antibody & bispecific delivery and efficacy
• Assessment of target gene expression by in situ staining or qPCR
• Collection of venous outflow for assessment of biomarkers

Attend this webinar to learn:

• How responses in Vascularized Micro-Tumor chips compare to responses seen in patient tumors
• What types of drug, cell-based and gene therapy studies can be conducted using Vascularized-Micro Tumor chips
• How Vascularized Micro-Tumor chips compare to other models, such as 2D cell culture or spheroid models

Chris Hughes

CSO at Aracari Biosciences